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Crystal structure of the human TBC1D20 rabgap domain

Analyse Crystal structure of the human TBC1D20 rabgap domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HL4
Type: protein
Length: 280 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TBC1 domain family member 20
UniProt: Q96BZ9
Ligands: BEF
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TBC1 domain family member 20	protein	280	64% helix, 0% strand	Q96BZ9

Ligands and binding sites

BEF · Beryllium trifluoride ion · ligand · chains A
ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.51	0.85	15	empty
2	51	0.25	0.73	15	empty

Compared structures

4HL4 · Crystal structure of the human TBC1D20 RabGAP domain · the same entry in another collection · chain A against A, TM-score 1.00
Q96BZ9 · AlphaFold monomer V2.0 prediction for TBC1 domain family member 20 (Q96BZ9) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96BZ9
Elsewhere: RCSB PDB 4HL4 · PDBe 4HL4 · UniProt Q96BZ9

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