Research workbench
Influenza hemagglutinin in complex with CH67 Fab
Analyse Influenza hemagglutinin in complex with CH67 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HKX
- Type
- protein
- Length
- 639 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin HA1; CH67 heavy chain; CH67 light chain
- UniProt
- A7UPX0
- Ligands
- NAG
- Pockets
- 8 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Hemagglutinin HA1 | protein | 212 | 13% helix, 38% strand | A7UPX0 |
| A | CH67 heavy chain | protein | 226 | 8% helix, 49% strand | — |
| B | CH67 light chain | protein | 201 | 8% helix, 51% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 722 | 0.66 | 0.75 | 71 | empty |
| 2 | 167 | 0.65 | 0.85 | 39 | empty |
| 3 | 155 | 0.63 | 0.85 | 24 | empty |
| 4 | 129 | 0.46 | 0.78 | 26 | empty |
| 5 | 72 | 0.44 | 0.81 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1881 Ų buried · 10 hydrogen bonds · protein-protein
- E–A · 604 Ų buried · 11 hydrogen bonds · protein-protein
- E–B · 317 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 4HKX · Influenza hemagglutinin in complex with CH67 Fab · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7UPX0
- Elsewhere: RCSB PDB 4HKX · PDBe 4HKX · UniProt A7UPX0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.