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The crystal structure of tetr transcriptional regulator (LMO2814) from listeria monocytogenes egd-E

Analyse The crystal structure of tetr transcriptional regulator (LMO2814) from listeria… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HKU
Type: protein
Length: 347 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tetr transcriptional regulator
UniProt: Q8Y3M1
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tetr transcriptional regulator	protein	174	77% helix, 0% strand	Q8Y3M1
B	Tetr transcriptional regulator	protein	173	76% helix, 0% strand	Q8Y3M1

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	297	0.71	0.85	39	empty
2	273	0.71	0.85	32	empty
3	67	0.33	0.75	13	empty
4	57	0.29	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 964 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

4HKU · The crystal structure of TetR transcriptional regulator (lmo2814) from Listeria… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8Y3M1
Elsewhere: RCSB PDB 4HKU · PDBe 4HKU · UniProt Q8Y3M1

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