Research workbench

GCN4PLI derivative with ALPHA/BETA/CYCLIC-gamma amino acid substitution pattern

Analyse GCN4PLI derivative with ALPHA/BETA/CYCLIC-gamma amino acid substitution pattern in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HJB
Type: protein
Length: 118 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GCN4PLI(ALPHA/BETA/CYCLIC-gamma)
Ligands: ACE

Structure

x-ray diffraction · 2 distinct chains · 86% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, D	GCN4PLI(ALPHA/BETA/CYCLIC-gamma)	protein	30	80% helix, 0% strand	—
A, B	GCN4PLI(ALPHA/BETA/CYCLIC-gamma)	protein	29	93% helix, 0% strand	—

Ligands and binding sites

ACE · Acetyl group · ligand · 4 copies · chains C, A, B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

4 interfaces between chains.

C–A · 840 Å² buried · 5 hydrogen bonds · protein-protein
B–D · 787 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 153 Å² buried · 1 hydrogen bond · protein-protein
A–D · 152 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 12 modified, 4 covalent (nonstandard, covalent ligand).

Compared structures

4HJB · GCN4pLI derivative with alpha/beta/cyclic-gamma amino acid substitution pattern · the same entry in another collection · chain D against D, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4HJB · PDBe 4HJB

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