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Crystal structure of schizosaccharomyces pombe POT1PC bound to ssdna (cggttacggt)

Analyse Crystal structure of schizosaccharomyces pombe POT1PC bound to ssdna… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HJ9
Type: protein + DNA
Length: 149 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protection of telomeres protein 1; DNA (5'-D(*CP*GP*GP*TP*TP*AP*CP*GP*GP*T)-3')
UniProt: O13988
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protection of telomeres protein 1	protein	139	16% helix, 34% strand	O13988
B	DNA (5'-D(CPGPGPTPTPAPCPGPGPT)-3')	dna	10	—	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.46	0.80	13	empty
2	60	0.38	0.80	21	empty

Interfaces

1 interface between chains.

A–B · 1103 Å² buried · 27 hydrogen bonds · protein-nucleic

Compared structures

4HJ9 · Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (CGGTTACGGT) · the same entry in another collection · chain A against A, TM-score 1.00
O13988 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (O13988) · a predicted model of the same protein · chain A against A, TM-score 0.94

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O13988
Elsewhere: RCSB PDB 4HJ9 · PDBe 4HJ9 · UniProt O13988

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