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Crystal structure of H112W mutant of borna disease virus matrix protein
Analyse Crystal structure of H112W mutant of borna disease virus matrix protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HIT
- Type
- protein
- Length
- 522 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Matrix protein
- UniProt
- P0C794
- Ligands
- SO4, CL
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 3 distinct chains · 22% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Matrix protein | protein | 135 | 22% helix, 35% strand | P0C794 |
| C | Matrix protein | protein | 124 | 21% helix, 37% strand | P0C794 |
| B | Matrix protein | protein | 128 | 23% helix, 38% strand | P0C794 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 9 copies · chains A, B, D, C
- CL · Chloride ion · ion · 2 copies · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 367 | 0.63 | 0.78 | 57 | SO4 |
| 2 | 76 | 0.41 | 0.79 | 20 | empty |
| 3 | 100 | 0.39 | 0.76 | 16 | empty |
| 4 | 54 | 0.32 | 0.77 | 16 | empty |
| 5 | 52 | 0.29 | 0.76 | 15 | SO4 |
Interfaces
5 interfaces between chains.
- A–B · 1173 Ų buried · 14 hydrogen bonds · protein-protein
- D–C · 1108 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 1108 Ų buried · 17 hydrogen bonds · protein-protein
- C–B · 992 Ų buried · 13 hydrogen bonds · protein-protein
- D–B · 37 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4HIT · Crystal structure of H112W mutant of borna disease virus matrix protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C794
- Elsewhere: RCSB PDB 4HIT · PDBe 4HIT · UniProt P0C794
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