Research workbench
Crystal structure of iscr bound to its promoter
Analyse Crystal structure of iscr bound to its promoter in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HF1
- Type
- protein + DNA
- Length
- 316 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hth-type transcriptional regulator iscr; DNA (29-mer)
- UniProt
- P0AGK8
- Pockets
- 6 · best druggability 0.58
Structure
x-ray diffraction · 4 distinct chains · 59% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hth-type transcriptional regulator iscr | protein | 129 | 56% helix, 11% strand | P0AGK8 |
| B | Hth-type transcriptional regulator iscr | protein | 129 | 62% helix, 9% strand | P0AGK8 |
| C | DNA (29-mer) | dna | 29 | — | — |
| D | DNA (29-mer) | dna | 29 | — | — |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 306 | 0.58 | 0.77 | 31 | empty |
| 2 | 171 | 0.46 | 0.76 | 17 | empty |
| 3 | 115 | 0.42 | 0.77 | 24 | empty |
| 4 | 54 | 0.42 | 0.82 | 15 | empty |
| 5 | 64 | 0.37 | 0.78 | 15 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1737 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1273 Ų buried · 126 hydrogen bonds · nucleic-nucleic
- A–C · 572 Ų buried · 14 hydrogen bonds · protein-nucleic
- B–D · 560 Ų buried · 10 hydrogen bonds · protein-nucleic
- B–C · 521 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AGK8
- Elsewhere: RCSB PDB 4HF1 · PDBe 4HF1 · UniProt P0AGK8
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