Research workbench
Lipoxygenase-3 (soybean) complex with 4-hydroperoxy-2-methoxy-phenol
Analyse Lipoxygenase-3 (soybean) complex with 4-hydroperoxy-2-methoxy-phenol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HU9
- Type
- protein
- Length
- 849 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lipoxygenase-3
- EC
- 1.13.11.12
- UniProt
- P09186
- Ligands
- 4HM, FE
- Pockets
- 12 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lipoxygenase-3 (EC 1.13.11.12) | protein | 849 | 38% helix, 15% strand | P09186 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 712 | 0.81 | 0.85 | 69 | empty |
| 2 | 64 | 0.73 | 0.98 | 20 | 4HM |
| 3 | 494 | 0.72 | 0.81 | 42 | empty |
| 4 | 59 | 0.71 | 0.98 | 22 | empty |
| 5 | 410 | 0.69 | 0.81 | 40 | empty |
Compared structures
- 1HU9 · Lipoxygenase-3 (soybean) complex with 4-hydroperoxy-2-methoxy-phenol · the same entry in another collection · chain A against A, TM-score 1.00
- P09186 · AlphaFold monomer V2.0 prediction for seed linoleate 9S-lipoxygenase-3 (P09186) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09186
- Elsewhere: RCSB PDB 1HU9 · PDBe 1HU9 · UniProt P09186
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