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Structure of the Q29T ISDX2-NEAT5 mutant in complex with heme

Analyse Structure of the Q29T ISDX2-NEAT5 mutant in complex with heme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4H8Q
Type: protein
Length: 119 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Iron transport-associated domain protein
UniProt: Q81L45
Ligands: HEM, ZN
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 62% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Iron transport-associated domain protein	protein	119	9% helix, 62% strand	Q81L45

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.51	0.83	17	HEM

Compared structures

4H8Q · Structure of the Q29T IsdX2-NEAT5 mutant in complex with heme · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q81L45
Elsewhere: RCSB PDB 4H8Q · PDBe 4H8Q · UniProt Q81L45

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