Research workbench
Crystal structure of a parallel 6-helix coiled coil cc-hex-N24
Analyse Crystal structure of a parallel 6-helix coiled coil cc-hex-N24 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4H8O
- Type
- protein
- Length
- 180 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cc-hex-N24
- Ligands
- ACE, NH2
- Pockets
- 1 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Cc-hex-N24 | protein | 30 | 93% helix, 0% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · 6 copies · chains A, B, C, D, E, F
- NH2 · Amino group · ion · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 459 | 0.84 | 0.89 | 48 | empty |
Interfaces
6 interfaces between chains.
- D–F · 702 Ų buried · 2 hydrogen bonds · protein-protein
- B–F · 696 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 692 Ų buried · 2 hydrogen bonds · protein-protein
- C–E · 691 Ų buried · 2 hydrogen bonds · protein-protein
- A–E · 685 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 covalent (covalent ligand).
Compared structures
- 4H8O · Crystal structure of a parallel 6-helix coiled coil CC-Hex-N24 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4H8O · PDBe 4H8O
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