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Middle domain of human EIF4GII

Analyse Middle domain of human EIF4GII in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1HU3
Type: protein
Length: 204 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: EIF4GII
UniProt: O43432
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	EIF4GII	protein	204	74% helix, 0% strand	O43432

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.37	0.77	11	empty
2	73	0.36	0.77	15	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

1HU3 · Middle domain of human EIF4GII · the same entry in another collection · chain A against A, TM-score 1.00
O43432 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4 gamma 3… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43432
Elsewhere: RCSB PDB 1HU3 · PDBe 1HU3 · UniProt O43432

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