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Crystal structure of the tetratricopeptide repeat (tpr) motif of human dual specificity protein kinase MPS1
Analyse Crystal structure of the tetratricopeptide repeat (tpr) motif of human dual… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4H7Y
- Type
- protein
- Length
- 556 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity protein kinase ttk
- EC
- 2.7.12.1
- UniProt
- P33981
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 74% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity protein kinase ttk (EC 2.7.12.1) | protein | 141 | 73% helix, 1% strand | P33981 |
| B | Dual specificity protein kinase ttk (EC 2.7.12.1) | protein | 139 | 74% helix, 1% strand | P33981 |
| C, D | Dual specificity protein kinase ttk (EC 2.7.12.1) | protein | 138 | 75% helix, 1% strand | P33981 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 872 | 0.75 | 0.79 | 72 | empty |
| 2 | 660 | 0.70 | 0.78 | 57 | empty |
| 3 | 111 | 0.52 | 0.83 | 23 | empty |
| 4 | 98 | 0.37 | 0.75 | 24 | empty |
| 5 | 77 | 0.35 | 0.76 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–D · 970 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 940 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 751 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 71 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 51 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4H7Y · Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33981
- Elsewhere: RCSB PDB 4H7Y · PDBe 4H7Y · UniProt P33981
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