Research workbench
Crystal and molecular structures of human progastricsin at 1.62 ångströms resolution
Analyse Crystal and molecular structures of human progastricsin at 1.62 ångströms… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HTR
- Type
- protein
- Length
- 372 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Progastricsin (pro segment); Gastricsin
- EC
- 3.4.23.3
- UniProt
- P20142
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| P | Progastricsin (pro segment) (EC 3.4.23.3) | protein | 43 | 40% helix, 16% strand | P20142 |
| B | Gastricsin (EC 3.4.23.3) | protein | 329 | 16% helix, 44% strand | P20142 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 522 | 0.71 | 0.80 | 56 | empty |
| 2 | 58 | 0.40 | 0.81 | 15 | empty |
Interfaces
1 interface between chains.
- P–B · 2421 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1HTR · Crystal and molecular structures of human progastricsin at 1.62 ångströms resolution · the same entry in another collection · chain P against P, TM-score 1.00
- P20142 · AlphaFold monomer V2.0 prediction for gastricsin (P20142) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20142
- Elsewhere: RCSB PDB 1HTR · PDBe 1HTR · UniProt P20142
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