Research workbench
Crystal structure of toscana virus nucleocapsid protein hexamer
Analyse Crystal structure of toscana virus nucleocapsid protein hexamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4H5L
- Type
- protein
- Length
- 1,463 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein
- UniProt
- P21701
- Pockets
- 12 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 66% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoprotein | protein | 243 | 66% helix, 2% strand | P21701 |
| B | Nucleoprotein | protein | 244 | 67% helix, 2% strand | P21701 |
| C, D, E, F | Nucleoprotein | protein | 244 | 66% helix, 2% strand | P21701 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 538 | 0.79 | 0.85 | 63 | empty |
| 2 | 639 | 0.78 | 0.83 | 66 | empty |
| 3 | 378 | 0.76 | 0.86 | 46 | empty |
| 4 | 578 | 0.75 | 0.82 | 65 | empty |
| 5 | 382 | 0.72 | 0.83 | 48 | empty |
Interfaces
6 interfaces between chains.
- E–F · 1804 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 1788 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 1656 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1636 Ų buried · 13 hydrogen bonds · protein-protein
- A–F · 1635 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4H5L · Crystal Structure of Toscana Virus Nucleocapsid Protein Hexamer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21701
- Elsewhere: RCSB PDB 4H5L · PDBe 4H5L · UniProt P21701
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