Research workbench
Crystal structure of the guanine nucleotide exchange factor SEC12 (P1 form)
Analyse Crystal structure of the guanine nucleotide exchange factor SEC12 (P1 form) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4H5I
- Type
- protein
- Length
- 689 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-exchange factor SEC12
- UniProt
- P11655
- Ligands
- K
- Pockets
- 4 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-exchange factor SEC12 | protein | 344 | 3% helix, 53% strand | P11655 |
| B | Guanine nucleotide-exchange factor SEC12 | protein | 345 | 3% helix, 53% strand | P11655 |
Ligands and binding sites
- K · Potassium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1071 | 0.87 | 0.88 | 120 | empty |
| 2 | 55 | 0.48 | 0.85 | 16 | empty |
| 3 | 105 | 0.46 | 0.80 | 19 | empty |
| 4 | 99 | 0.43 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 536 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 4H5I · Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P1 form) · the same entry in another collection · chain A against A, TM-score 1.00
- P11655 · AlphaFold monomer V2.0 prediction for guanine nucleotide-exchange factor SEC12 (P11655) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11655
- Elsewhere: RCSB PDB 4H5I · PDBe 4H5I · UniProt P11655
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