Research workbench
Structure of the CMR2-CMR3 subcomplex of the cmr RNA-silencing complex
Analyse Structure of the CMR2-CMR3 subcomplex of the cmr RNA-silencing complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4H4K
- Type
- protein
- Length
- 863 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR system cmr subunit CMR3; CRISPR system cmr subunit CMR2
- UniProt
- Q8U1S7, Q8U1S6
- Ligands
- ATP, NA, ZN
- Pockets
- 13 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CRISPR system cmr subunit CMR3 | protein | 259 | 15% helix, 42% strand | Q8U1S7 |
| C | CRISPR system cmr subunit CMR2 | protein | 604 | 54% helix, 13% strand | Q8U1S6 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A, C
- NA · Sodium ion · metal · 2 copies · chains C
- ZN · Zinc ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1123 | 0.77 | 0.79 | 78 | ATP, NA |
| 2 | 280 | 0.59 | 0.78 | 42 | empty |
| 3 | 368 | 0.56 | 0.75 | 39 | empty |
| 4 | 255 | 0.56 | 0.77 | 41 | empty |
| 5 | 130 | 0.54 | 0.82 | 17 | empty |
Interfaces
1 interface between chains.
- A–C · 1784 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 4H4K · Structure of the Cmr2-Cmr3 subcomplex of the Cmr RNA-silencing complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8U1S7 · AlphaFold monomer V2.0 prediction for CRISPR system cmr subunit CMR3 (Q8U1S7) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q8U1S6 · AlphaFold monomer V2.0 prediction for CRISPR system cmr subunit CMR2 (Q8U1S6) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U1S7
- Every structure of UniProt Q8U1S6
- Elsewhere: RCSB PDB 4H4K · PDBe 4H4K · UniProt Q8U1S7 · UniProt Q8U1S6
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