Research workbench
Structure of influenza haemagglutinin at the pH of membrane fusion
Analyse Structure of influenza haemagglutinin at the pH of membrane fusion in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HTM
- Type
- protein
- Length
- 379 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin HA1 chain; Hemagglutinin HA2 chain
- UniProt
- P03437
- Pockets
- 5 · best druggability 0.47
Structure
x-ray diffraction · 5 distinct chains · 67% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemagglutinin HA1 chain | protein | 5 | 0% helix, 40% strand | P03437 |
| B | Hemagglutinin HA2 chain | protein | 114 | 75% helix, 4% strand | P03437 |
| C | Hemagglutinin HA1 chain | protein | 6 | 0% helix, 50% strand | P03437 |
| D, F | Hemagglutinin HA2 chain | protein | 123 | 70% helix, 5% strand | P03437 |
| E | Hemagglutinin HA1 chain | protein | 8 | 0% helix, 50% strand | P03437 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.47 | 0.76 | 28 | empty |
| 2 | 136 | 0.43 | 0.76 | 24 | empty |
| 3 | 74 | 0.35 | 0.76 | 15 | empty |
| 4 | 88 | 0.34 | 0.75 | 14 | empty |
| 5 | 76 | 0.33 | 0.75 | 15 | empty |
Interfaces
6 interfaces between chains.
- B–F · 1827 Ų buried · 23 hydrogen bonds · protein-protein
- D–F · 1704 Ų buried · 19 hydrogen bonds · protein-protein
- B–D · 1650 Ų buried · 14 hydrogen bonds · protein-protein
- E–F · 535 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 401 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1HTM · Structure of influenza haemagglutinin at the pH of membrane fusion · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03437
- Elsewhere: RCSB PDB 1HTM · PDBe 1HTM · UniProt P03437
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