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Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid membranes

Analyse Crystal structure of a voltage-gated K+ channel pore domain in a closed state… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4H37
Type: protein
Length: 172 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: LMO2059 protein
UniProt: Q8Y5K1
Ligands: K
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	LMO2059 protein	protein	86	74% helix, 0% strand	Q8Y5K1

Ligands and binding sites

K · Potassium ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	98	0.36	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 903 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4H37 · Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8Y5K1
Elsewhere: RCSB PDB 4H37 · PDBe 4H37 · UniProt Q8Y5K1

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