Research workbench
Crystal structure of JNK3 in complex with ATF2 peptide
Analyse Crystal structure of JNK3 in complex with ATF2 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4H36
- Type
- protein
- Length
- 361 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 10; Cyclic AMP-dependent transcription factor atf-2
- EC
- 2.7.11.24
- UniProt
- P53779, P15336
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 10 (EC 2.7.11.24) | protein | 353 | 39% helix, 16% strand | P53779 |
| B | Cyclic AMP-dependent transcription factor atf-2 | protein | 8 | 0% helix, 0% strand | P15336 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.56 | 0.86 | 20 | empty |
| 2 | 57 | 0.50 | 0.86 | 20 | empty |
| 3 | 63 | 0.28 | 0.73 | 15 | empty |
| 4 | 52 | 0.27 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 501 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4H36 · Crystal Structure of JNK3 in Complex with ATF2 Peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P53779 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 10 (P53779) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P15336 · AlphaFold monomer V2.0 prediction for cyclic AMP-dependent transcription factor atf-2… · a predicted model of the same protein · chain B against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53779
- Every structure of UniProt P15336
- Elsewhere: RCSB PDB 4H36 · PDBe 4H36 · UniProt P53779 · UniProt P15336
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