Research workbench
Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1
Analyse Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4H22
- Type
- protein
- Length
- 312 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat flightless-interacting protein 1
- UniProt
- Q32MZ4
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 3 distinct chains · 94% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-rich repeat flightless-interacting protein 1 | protein | 81 | 89% helix, 0% strand | Q32MZ4 |
| B | Leucine-rich repeat flightless-interacting protein 1 | protein | 83 | 98% helix, 0% strand | Q32MZ4 |
| C, D | Leucine-rich repeat flightless-interacting protein 1 | protein | 74 | 96% helix, 0% strand | Q32MZ4 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.42 | 0.82 | 15 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2430 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 2206 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 451 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 446 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 253 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4H22 · Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor… · the same entry in another collection · chain A against A, TM-score 1.00
- Q32MZ4 · AlphaFold monomer V2.0 prediction for leucine-rich repeat flightless- interacting protein… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q32MZ4
- Elsewhere: RCSB PDB 4H22 · PDBe 4H22 · UniProt Q32MZ4
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