Research workbench
Crystal structure of a periplasmic thioredoxin-like protein from salmonella enterica serovar typhimurium
Analyse Crystal structure of a periplasmic thioredoxin-like protein from salmonella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GXZ
- Type
- protein
- Length
- 698 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppression of copper sensitivity protein
- EC
- 5.3.4.1
- UniProt
- H9L4C1
- Pockets
- 7 · best druggability 0.62
Structure
x-ray diffraction · 4 distinct chains · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppression of copper sensitivity protein (EC 5.3.4.1) | protein | 178 | 54% helix, 13% strand | H9L4C1 |
| B | Suppression of copper sensitivity protein (EC 5.3.4.1) | protein | 176 | 55% helix, 14% strand | H9L4C1 |
| C | Suppression of copper sensitivity protein (EC 5.3.4.1) | protein | 174 | 53% helix, 14% strand | H9L4C1 |
| D | Suppression of copper sensitivity protein (EC 5.3.4.1) | protein | 170 | 54% helix, 14% strand | H9L4C1 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.62 | 0.80 | 49 | empty |
| 2 | 194 | 0.57 | 0.80 | 29 | empty |
| 3 | 153 | 0.52 | 0.79 | 18 | empty |
| 4 | 95 | 0.47 | 0.81 | 25 | empty |
| 5 | 102 | 0.46 | 0.79 | 14 | empty |
Interfaces
5 interfaces between chains.
- A–B · 750 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 508 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 185 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 167 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 164 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4GXZ · Crystal structure of a periplasmic thioredoxin-like protein from Salmonella enterica… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H9L4C1
- Elsewhere: RCSB PDB 4GXZ · PDBe 4GXZ · UniProt H9L4C1
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