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The human W42R gamma D-crystallin mutant structure at 1.7A resolution

Analyse The human W42R gamma D-crystallin mutant structure at 1.7A resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GR7
Type: protein
Length: 346 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-crystallin D
UniProt: P07320
Ligands: PO4
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X, A	Gamma-crystallin D	protein	173	10% helix, 44% strand	P07320

Ligands and binding sites

PO4 · Phosphate ion · ion · chains X, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	323	0.68	0.82	37	PO4
2	81	0.51	0.84	23	empty
3	70	0.47	0.83	19	empty

Interfaces

1 interface between chains.

X–A · 963 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4GR7 · The human W42R Gamma D-Crystallin Mutant Structure at 1.7A Resolution · the same entry in another collection · chain X against X, TM-score 1.00
P07320 · AlphaFold monomer V2.0 prediction for gamma-crystallin D (P07320) · a predicted model of the same protein · chain X against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07320
Elsewhere: RCSB PDB 4GR7 · PDBe 4GR7 · UniProt P07320

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