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The 3D structure of the human sry-DNA complex solved by multi- dimensional heteronuclear-edited and-filtered NMR

Analyse The 3D structure of the human sry-DNA complex solved by multi- dimensional… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1HRZ
Type
protein + DNA
Length
89 residues
Chains
3
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'-D(*GP*CP*AP*CP*AP*AP*AP*C)-3'); DNA (5'-D(*GP*TP*TP*TP*GP*TP*GP*C)-3'); Human sry
UniProt
Q05066
Pockets
1 · best druggability 0.72

Structure

solution nmr · 3 distinct chains · 64% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
BDNA (5'-D(*GP*CP*AP*CP*AP*AP*AP*C)-3')dna8——
CDNA (5'-D(*GP*TP*TP*TP*GP*TP*GP*C)-3')dna8——
AHuman sryprotein7364% helix, 0% strandQ05066

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12720.720.8629empty

Interfaces

3 interfaces between chains.

  • B–A · 550 Ų buried · 5 hydrogen bonds · protein-nucleic
  • C–A · 479 Ų buried · 6 hydrogen bonds · protein-nucleic
  • B–C · 365 Ų buried · 25 hydrogen bonds · nucleic-nucleic

Compared structures

  • 1HRZ · The 3D structure of the human sry-DNA complex solved by multi-dimensional… · the same entry in another collection · chain B against B, TM-score 1.00
  • Q05066 · AlphaFold monomer V2.0 prediction for sex-determining region Y protein (Q05066) · a predicted model of the same protein · chain A against A, TM-score 0.57

Analyse

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