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Crystal structure of the GET5 ubiquitin-like domain

Analyse Crystal structure of the GET5 ubiquitin-like domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GOC
Type: protein
Length: 228 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Golgi to er traffic protein 5
UniProt: Q12285
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Golgi to er traffic protein 5	protein	76	21% helix, 38% strand	Q12285

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	234	0.56	0.78	29	empty

Interfaces

3 interfaces between chains.

B–C · 620 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 434 Å² buried · 6 hydrogen bonds · protein-protein
A–B · 256 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4GOC · Crystal structure of the Get5 ubiquitin-like domain · the same entry in another collection · chain A against A, TM-score 1.00
Q12285 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein MDY2 (Q12285) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12285
Elsewhere: RCSB PDB 4GOC · PDBe 4GOC · UniProt Q12285

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