Research workbench
Crystal structure of full length transcription repressor lsrr from E. COLI.
Analyse Crystal structure of full length transcription repressor lsrr from E. COLI. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GO1
- Type
- protein
- Length
- 593 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator lsrr
- UniProt
- P76141
- Pockets
- 7 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator lsrr | protein | 297 | 44% helix, 16% strand | P76141 |
| B | Transcriptional regulator lsrr | protein | 296 | 48% helix, 16% strand | P76141 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.60 | 0.81 | 30 | empty |
| 2 | 161 | 0.43 | 0.74 | 31 | GOL |
| 3 | 101 | 0.40 | 0.77 | 16 | empty |
| 4 | 146 | 0.40 | 0.73 | 24 | empty |
| 5 | 77 | 0.36 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1851 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 4GO1 · Crystal Structure of full length transcription repressor LsrR from E. coli. · the same entry in another collection · chain A against A, TM-score 1.00
- P76141 · AlphaFold monomer V2.0 prediction for transcriptional regulator lsrr (P76141) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P76141
- Elsewhere: RCSB PDB 4GO1 · PDBe 4GO1 · UniProt P76141
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