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Crystal structure of enterovirus 71 strain 1095 procapsid

Analyse Crystal structure of enterovirus 71 strain 1095 procapsid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GMP
Type: protein
Length: 695 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Capsid protein VP0; Capsid protein VP1; Capsid protein VP3
UniProt: E5RPG0
Pockets: 7 · best druggability 0.66

Structure

x-ray diffraction · 3 distinct chains · 9% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
0	Capsid protein VP0	protein	237	11% helix, 31% strand	E5RPG0
1	Capsid protein VP1	protein	218	6% helix, 32% strand	E5RPG0
3	Capsid protein VP3	protein	240	10% helix, 33% strand	E5RPG0

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	326	0.66	0.81	32	empty
2	268	0.55	0.77	38	empty
3	153	0.50	0.78	27	empty
4	138	0.49	0.79	28	empty
5	227	0.48	0.74	38	empty

Interfaces

3 interfaces between chains.

1–3 · 3177 Å² buried · 45 hydrogen bonds · protein-protein
0–1 · 1837 Å² buried · 33 hydrogen bonds · protein-protein
0–3 · 1589 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

4GMP · Crystal structure of enterovirus 71 strain 1095 procapsid · the same entry in another collection · chain 0 against 0, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E5RPG0
Elsewhere: RCSB PDB 4GMP · PDBe 4GMP · UniProt E5RPG0

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