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The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.

Analyse The crystal structure of soluble human CD14 reveals a bent solenoid with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GLP
Type: protein
Length: 310 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Monocyte differentiation antigen CD14
UniProt: P08571
Pockets: 4 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Monocyte differentiation antigen CD14	protein	310	15% helix, 12% strand	P08571

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	712	0.79	0.83	47	empty
2	147	0.72	0.90	30	empty
3	89	0.60	0.88	30	empty
4	77	0.36	0.76	16	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

4GLP · The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic… · the same entry in another collection · chain A against A, TM-score 1.00
P08571 · AlphaFold monomer V2.0 prediction for monocyte differentiation antigen CD14 (P08571) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08571
Elsewhere: RCSB PDB 4GLP · PDBe 4GLP · UniProt P08571

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