Research workbench
Crystal structure of CD23 lectin domain mutant E249A
Analyse Crystal structure of CD23 lectin domain mutant E249A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GI0
- Type
- protein
- Length
- 400 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Low affinity immunoglobulin epsilon Fc receptor
- UniProt
- P06734
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Low affinity immunoglobulin epsilon Fc receptor | protein | 136 | 15% helix, 39% strand | P06734 |
| B | Low affinity immunoglobulin epsilon Fc receptor | protein | 129 | 18% helix, 36% strand | P06734 |
| C | Low affinity immunoglobulin epsilon Fc receptor | protein | 135 | 15% helix, 38% strand | P06734 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 544 | 0.62 | 0.75 | 52 | empty |
| 2 | 118 | 0.39 | 0.74 | 24 | empty |
Interfaces
2 interfaces between chains.
- A–C · 355 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 307 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 4GI0 · Crystal structure of CD23 lectin domain mutant E249A · the same entry in another collection · chain A against A, TM-score 1.00
- P06734 · AlphaFold monomer V2.0 prediction for low affinity immunoglobulin epsilon Fc receptor… · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06734
- Elsewhere: RCSB PDB 4GI0 · PDBe 4GI0 · UniProt P06734
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