Research workbench
X-ray crystal structure of gamma-glutamyl phosphate reductase from burkholderia thailandensis
Analyse X-ray crystal structure of gamma-glutamyl phosphate reductase from burkholderia… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GHK
- Type
- protein
- Length
- 1,612 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-glutamyl phosphate reductase
- EC
- 1.2.1.41
- UniProt
- Q2SZ88
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 47% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma-glutamyl phosphate reductase (EC 1.2.1.41) | protein | 404 | 46% helix, 21% strand | Q2SZ88 |
| B | Gamma-glutamyl phosphate reductase (EC 1.2.1.41) | protein | 410 | 48% helix, 22% strand | Q2SZ88 |
| C | Gamma-glutamyl phosphate reductase (EC 1.2.1.41) | protein | 398 | 46% helix, 21% strand | Q2SZ88 |
| D | Gamma-glutamyl phosphate reductase (EC 1.2.1.41) | protein | 400 | 46% helix, 22% strand | Q2SZ88 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1155 | 0.80 | 0.82 | 122 | empty |
| 2 | 966 | 0.77 | 0.80 | 80 | empty |
| 3 | 449 | 0.77 | 0.85 | 51 | empty |
| 4 | 457 | 0.75 | 0.84 | 57 | empty |
| 5 | 383 | 0.60 | 0.76 | 45 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2883 Ų buried · 53 hydrogen bonds · protein-protein
- A–B · 2873 Ų buried · 47 hydrogen bonds · protein-protein
- B–C · 956 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 944 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 273 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4GHK · X-ray Crystal Structure of Gamma-glutamyl phosphate reductase from Burkholderia… · the same entry in another collection · chain D against D, TM-score 1.00
- Q2SZ88 · AlphaFold monomer V2.0 prediction for gamma-glutamyl phosphate reductase (Q2SZ88) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2SZ88
- Elsewhere: RCSB PDB 4GHK · PDBe 4GHK · UniProt Q2SZ88
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