Research workbench

Crystal structure of the tal effector DHAX3 bound to specific DNA-RNA hybrid

Analyse Crystal structure of the tal effector DHAX3 bound to specific DNA-RNA hybrid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GG4
Type: protein + DNA + RNA
Length: 521 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HAX3; DNA (5'- D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'); RNA (5'…
UniProt: Q3ZD72
Pockets: 1 · best druggability 0.79

Structure

x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	HAX3	protein	488	73% helix, 0% strand	Q3ZD72
G	DNA (5'- D(TPGPTPCPCPCPTPTPTPAPTPCPTPCPTPCP*T)-3')	dna	17	—	—
H	RNA (5'- R(APGPAPGPAPGPAPUPAPAPAPGPGPGPAPCP*A)-3')	rna	16	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	932	0.79	0.82	109	empty

Interfaces

3 interfaces between chains.

A–G · 1747 Å² buried · 20 hydrogen bonds · protein-nucleic
G–H · 746 Å² buried · 66 hydrogen bonds · nucleic-nucleic
A–H · 331 Å² buried · 5 hydrogen bonds · protein-nucleic

Compared structures

4GG4 · Crystal structure of the TAL effector dHax3 bound to specific DNA-RNA hybrid · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3ZD72
Elsewhere: RCSB PDB 4GG4 · PDBe 4GG4 · UniProt Q3ZD72

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.