Research workbench
Crystal structure of glutahtione transferase homolog from sulfitobacter, target efi-501084, with bound glutathione
Analyse Crystal structure of glutahtione transferase homolog from sulfitobacter, target… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GF0
- Type
- protein
- Length
- 394 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase
- UniProt
- A3STM0
- Ligands
- GSH, CL
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutathione S-transferase | protein | 208 | 56% helix, 9% strand | A3STM0 |
| B | Glutathione S-transferase | protein | 186 | 58% helix, 9% strand | A3STM0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 407 | 0.72 | 0.83 | 45 | GSH |
| 2 | 373 | 0.66 | 0.80 | 50 | GSH |
| 3 | 141 | 0.51 | 0.80 | 22 | empty |
| 4 | 203 | 0.48 | 0.75 | 31 | empty |
| 5 | 54 | 0.44 | 0.83 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1800 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4GF0 · Crystal structure of glutahtione transferase homolog from sulfitobacter, TARGET… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3STM0
- Elsewhere: RCSB PDB 4GF0 · PDBe 4GF0 · UniProt A3STM0
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