Research workbench
Crystal structure of the nitrogen regulation fragment of the yeast prion protein URE2P
Analyse Crystal structure of the nitrogen regulation fragment of the yeast prion… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HQO
- Type
- protein
- Length
- 450 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- URE2 protein
- UniProt
- P23202
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | URE2 protein | protein | 227 | 59% helix, 8% strand | P23202 |
| B | URE2 protein | protein | 223 | 60% helix, 8% strand | P23202 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 515 | 0.73 | 0.82 | 36 | empty |
| 2 | 635 | 0.72 | 0.79 | 45 | empty |
| 3 | 225 | 0.59 | 0.80 | 29 | empty |
| 4 | 108 | 0.46 | 0.78 | 16 | empty |
| 5 | 125 | 0.41 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1902 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 1HQO · Crystal structure of the nitrogen regulation fragment of the yeast prion protein URE2P · the same entry in another collection · chain A against A, TM-score 1.00
- P23202 · AlphaFold monomer V2.0 prediction for transcriptional regulator URE2 (P23202) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23202
- Elsewhere: RCSB PDB 1HQO · PDBe 1HQO · UniProt P23202
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