Solution NMR structure of the GRB2 N-terminal SH3 domain complexed with a ten-residue peptide derived from sos direct refinement against noes, J-couplings, and 1H and 13C chemical shifts, 15 structures

Structure

solution nmr · 2 distinct chains · 4% helix, 40% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains A, B
• NH2 · Amino group · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 502 Ų buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 4GBQ · Solution NMR structure of the GRB2 N-terminal SH3 domain complexed with a ten-residue… · the same entry in another collection · chain A against A, TM-score 1.00
• Q60631 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 2 (Q60631) · a predicted model of the same protein · chain A against A, TM-score 0.87
• Q62245 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q62245) · a predicted model of the same protein · chain B against A, TM-score 0.53

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q60631
• Every structure of UniProt Q62245
• Elsewhere: RCSB PDB 4GBQ · PDBe 4GBQ · UniProt Q60631 · UniProt Q62245