Research workbench
Crystal structure of ebi-005, a chimera of human il-1BETA and il-1RA
Analyse Crystal structure of ebi-005, a chimera of human il-1BETA and il-1RA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GAI
- Type
- protein
- Length
- 292 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ebi-005
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ebi-005 | protein | 152 | 6% helix, 48% strand | — |
| B | Ebi-005 | protein | 140 | 6% helix, 54% strand | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.60 | 0.79 | 29 | empty |
| 2 | 157 | 0.50 | 0.78 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 654 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4GAI · Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4GAI · PDBe 4GAI
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