Research workbench

Intact sensor domain of human RNase L in the inactive signaling state

Analyse Intact sensor domain of human RNase L in the inactive signaling state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4G8K
Type: protein
Length: 600 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2-5A-dependent ribonuclease
EC: 3.1.26.-
UniProt: Q05823
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	2-5A-dependent ribonuclease (EC 3.1.26.-)	protein	302	52% helix, 1% strand	Q05823
B	2-5A-dependent ribonuclease (EC 3.1.26.-)	protein	298	50% helix, 2% strand	Q05823

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	524	0.61	0.75	55	empty
2	59	0.29	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 670 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

4G8K · Intact sensor domain of human RNase L in the inactive signaling state · the same entry in another collection · chain A against A, TM-score 1.00
Q05823 · AlphaFold monomer V2.0 prediction for 2-5A-dependent ribonuclease (Q05823) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05823
Elsewhere: RCSB PDB 4G8K · PDBe 4G8K · UniProt Q05823

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