Research workbench
Crystal structure of CLONE18 TCR
Analyse Crystal structure of CLONE18 TCR in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4G8E
- Type
- protein
- Length
- 442 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha chain clone 18 TCR; Beta chain clone 18 TCR
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha chain clone 18 TCR | protein | 201 | 1% helix, 48% strand | — |
| B | Beta chain clone 18 TCR | protein | 241 | 7% helix, 51% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1108 | 0.75 | 0.77 | 85 | empty |
| 2 | 98 | 0.42 | 0.78 | 17 | empty |
| 3 | 87 | 0.37 | 0.76 | 21 | empty |
| 4 | 77 | 0.34 | 0.75 | 18 | empty |
| 5 | 80 | 0.32 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2208 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 4G8E · Crystal Structure of clone18 TCR · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4G8E · PDBe 4G8E
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