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Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state

Analyse Crystal structure of the therapeutic antibody binding fragment of gevokizumab… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4G6K
Type: protein
Length: 432 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heavy chain of gevokizumab antibody binding fragment; Light chain of gevokizumab antibody…
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Heavy chain of gevokizumab antibody binding fragment	protein	220	7% helix, 50% strand	—
L	Light chain of gevokizumab antibody binding fragment	protein	212	6% helix, 51% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	686	0.64	0.74	72	empty
2	74	0.35	0.76	19	empty
3	66	0.29	0.73	17	empty

Interfaces

1 interface between chains.

H–L · 1825 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4G6K · Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its… · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4G6K · PDBe 4G6K

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