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Crystal structure of beta-hexosaminidase 1 from burkholderia cenocepacia J2315

Analyse Crystal structure of beta-hexosaminidase 1 from burkholderia cenocepacia J2315 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4G6C
Type: protein
Length: 658 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-hexosaminidase 1
EC: 3.2.1.52
UniProt: B4EA43
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-hexosaminidase 1 (EC 3.2.1.52)	protein	333	46% helix, 13% strand	B4EA43
B	Beta-hexosaminidase 1 (EC 3.2.1.52)	protein	325	46% helix, 13% strand	B4EA43

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	766	0.81	0.84	87	empty
2	164	0.48	0.76	24	empty
3	132	0.46	0.77	21	empty
4	50	0.29	0.76	14	empty
5	52	0.25	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 1496 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

4G6C · Crystal structure of beta-hexosaminidase 1 from Burkholderia cenocepacia J2315 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B4EA43
Elsewhere: RCSB PDB 4G6C · PDBe 4G6C · UniProt B4EA43

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