Research workbench
Structure of the hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33
Analyse Structure of the hepatitis C virus envelope glycoprotein E2 antigenic region… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4G6A
- Type
- protein
- Length
- 901 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E2 peptide; AP33 heavy chain; AP33 light chain
- UniProt
- Q9YK84
- Pockets
- 10 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | E2 peptide | protein | 12 | 0% helix, 50% strand | Q9YK84 |
| C | AP33 heavy chain | protein | 220 | 5% helix, 52% strand | — |
| D, L | AP33 light chain | protein | 218 | 6% helix, 52% strand | — |
| H | AP33 heavy chain | protein | 221 | 5% helix, 52% strand | — |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 814 | 0.69 | 0.76 | 74 | empty |
| 2 | 739 | 0.67 | 0.75 | 57 | empty |
| 3 | 240 | 0.62 | 0.82 | 41 | empty |
| 4 | 50 | 0.51 | 0.88 | 23 | empty |
| 5 | 142 | 0.47 | 0.77 | 29 | empty |
Interfaces
9 interfaces between chains.
- H–L · 2140 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 2132 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 341 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 336 Ų buried · 5 hydrogen bonds · protein-protein
- A–H · 331 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 4G6A · Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9YK84
- Elsewhere: RCSB PDB 4G6A · PDBe 4G6A · UniProt Q9YK84
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.