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Crystal structure of cytosolic imp-gmp specific 5'-nucleotidase (LPG0095) in complex with phosphate ions from legionella pneumophila, northeast structural genomics consortium target LGR1

Analyse Crystal structure of cytosolic imp-gmp specific 5'-nucleotidase (LPG0095) in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4G63
Type: protein
Length: 454 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytosolic imp-gmp specific 5'-nucleotidase
UniProt: Q5ZZB6
Ligands: PO4
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytosolic imp-gmp specific 5'-nucleotidase	protein	454	45% helix, 17% strand	Q5ZZB6

Ligands and binding sites

PO4 · Phosphate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	218	0.76	0.90	37	empty
2	239	0.64	0.82	32	empty
3	191	0.51	0.77	36	empty
4	113	0.38	0.74	16	empty
5	51	0.26	0.74	17	empty

Compared structures

4G63 · Crystal structure of cytosolic IMP-GMP specific 5'-nucleotidase (lpg0095) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5ZZB6
Elsewhere: RCSB PDB 4G63 · PDBe 4G63 · UniProt Q5ZZB6

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