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Crystal structure of the N-terminal domain of helicobacter pylori caga protein

Analyse Crystal structure of the N-terminal domain of helicobacter pylori caga protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4G0H
Type: protein
Length: 450 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytotoxicity-associated immunodominant antigen
UniProt: P55980
Pockets: 11 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytotoxicity-associated immunodominant antigen	protein	450	60% helix, 16% strand	P55980

Pockets

11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	178	0.56	0.80	24	empty
2	262	0.53	0.76	38	empty
3	120	0.49	0.80	23	empty
4	129	0.48	0.79	20	empty
5	56	0.37	0.79	9	empty

Compared structures

4G0H · Crystal structure of the N-terminal domain of Helicobacter pylori CagA protein · the same entry in another collection · chain A against A, TM-score 1.00
P55980 · AlphaFold monomer V2.0 prediction for cytotoxicity-associated immunodominant antigen… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55980
Elsewhere: RCSB PDB 4G0H · PDBe 4G0H · UniProt P55980

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