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Crystal structure of human tirap tir-domain
Analyse Crystal structure of human tirap tir-domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FZ5
- Type
- protein
- Length
- 230 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TOLL/INTERLEUKIN-1 receptor domain-containing adapter protein
- UniProt
- P58753
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TOLL/INTERLEUKIN-1 receptor domain-containing adapter protein | protein | 116 | 41% helix, 16% strand | P58753 |
| B | TOLL/INTERLEUKIN-1 receptor domain-containing adapter protein | protein | 114 | 20% helix, 15% strand | P58753 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.46 | 0.77 | 26 | empty |
| 2 | 54 | 0.42 | 0.82 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 200 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P58753
- Elsewhere: RCSB PDB 4FZ5 · PDBe 4FZ5 · UniProt P58753
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