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Crystal structure of the fourth type of archaeal tRNA splicing endonuclease from candidatus micrarchaeum acidiphilum arman-2

Analyse Crystal structure of the fourth type of archaeal tRNA splicing endonuclease… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FZ2
Type: protein
Length: 772 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TRNA intron endonuclease
EC: 3.1.27.9
UniProt: C7DIA5
Pockets: 9 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	TRNA intron endonuclease (EC 3.1.27.9)	protein	386	30% helix, 29% strand	C7DIA5

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	389	0.63	0.78	41	empty
2	88	0.60	0.88	23	empty
3	96	0.55	0.85	19	empty
4	113	0.45	0.78	30	empty
5	107	0.42	0.77	23	empty

Interfaces

1 interface between chains.

A–B · 3112 Å² buried · 33 hydrogen bonds · protein-protein

Compared structures

4FZ2 · Crystal structure of the fourth type of archaeal tRNA splicing endonuclease from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C7DIA5
Elsewhere: RCSB PDB 4FZ2 · PDBe 4FZ2 · UniProt C7DIA5

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