Crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 41% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
• BMA · beta-D-mannopyranose · sugar · 2 copies
• SO4 · Sulfate ion · ion · 2 copies · chains A
• ACT · Acetate ion · additive · 5 copies · chains A
• GOL · Glycerol · additive · 4 copies · chains A
• EDO · 1,2-ethanediol · additive · 4 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 11 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 4FWW · Crystal structure of the Sema-PSI extracellular domains of human RON receptor tyrosine… · the same entry in another collection · chain A against A, TM-score 1.00
• Q04912 · AlphaFold monomer V2.0 prediction for macrophage-stimulating protein receptor (Q04912) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q04912
• Elsewhere: RCSB PDB 4FWW · PDBe 4FWW · UniProt Q04912