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Cid of human RPRD1B

Analyse Cid of human RPRD1B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FU3
Type: protein
Length: 255 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulation of nuclear pre-mRNA domain-containing protein 1B
UniProt: Q9NQG5
Ligands: UNX, CL
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulation of nuclear pre-mRNA domain-containing protein 1B	protein	127	74% helix, 0% strand	Q9NQG5
B	Regulation of nuclear pre-mRNA domain-containing protein 1B	protein	128	80% helix, 0% strand	Q9NQG5

Ligands and binding sites

UNX · Unknown atom or ion · ion · 10 copies · chains A, B
CL · Chloride ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.58	0.87	20	empty
2	107	0.40	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 454 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

4FU3 · CID of human RPRD1B · the same entry in another collection · chain A against A, TM-score 1.00
Q9NQG5 · AlphaFold monomer V2.0 prediction for regulation of nuclear pre-mRNA domain-containing… · a predicted model of the same protein · chain B against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NQG5
Elsewhere: RCSB PDB 4FU3 · PDBe 4FU3 · UniProt Q9NQG5

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