Research workbench
2.2A resolution structure of proteasome assembly chaperone HSM3
Analyse 2.2A resolution structure of proteasome assembly chaperone HSM3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FP7
- Type
- protein
- Length
- 870 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA mismatch repair protein HSM3
- UniProt
- P38348
- Pockets
- 6 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA mismatch repair protein HSM3 | protein | 452 | 73% helix, 0% strand | P38348 |
| B | DNA mismatch repair protein HSM3 | protein | 418 | 76% helix, 0% strand | P38348 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.62 | 0.84 | 32 | empty |
| 2 | 249 | 0.57 | 0.78 | 31 | empty |
| 3 | 195 | 0.53 | 0.78 | 22 | empty |
| 4 | 187 | 0.50 | 0.77 | 25 | empty |
| 5 | 64 | 0.27 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1558 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 4FP7 · 2.2A resolution structure of Proteasome Assembly Chaperone Hsm3 · the same entry in another collection · chain A against A, TM-score 1.00
- P38348 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein HSM3 (P38348) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38348
- Elsewhere: RCSB PDB 4FP7 · PDBe 4FP7 · UniProt P38348
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