Research workbench
Elongation factor G 1 (pseudomonas aeruginosa) in complex with argyrin B
Analyse Elongation factor G 1 (pseudomonas aeruginosa) in complex with argyrin B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FN5
- Type
- protein
- Length
- 678 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor G 1; Argyrin B
- UniProt
- Q9HWD2
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor G 1 | protein | 670 | 30% helix, 30% strand | Q9HWD2 |
| B | Argyrin B | protein | 8 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 408 | 0.65 | 0.79 | 49 | empty |
| 2 | 125 | 0.62 | 0.86 | 21 | empty |
| 3 | 111 | 0.56 | 0.84 | 19 | empty |
| 4 | 67 | 0.39 | 0.79 | 12 | empty |
| 5 | 97 | 0.35 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 642 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified, 1 d-amino (nonstandard, D-amino acid, methylation).
Compared structures
- 4FN5 · ELONGATION FACTOR G 1 (PSEUDOMONAS AERUGINOSA) IN COMPLEX WITH Argyrin B · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HWD2 · AlphaFold monomer V2.0 prediction for elongation factor G 1 (Q9HWD2) · a predicted model of the same protein · chain A against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HWD2
- Elsewhere: RCSB PDB 4FN5 · PDBe 4FN5 · UniProt Q9HWD2
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