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Crystal structure of ureidoglycolate dehydrogenase enzyme in apo form

Analyse Crystal structure of ureidoglycolate dehydrogenase enzyme in apo form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FJS
Type: protein
Length: 652 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ureidoglycolate dehydrogenase
EC: 1.1.1.154
UniProt: B1XGB5
Pockets: 5 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ureidoglycolate dehydrogenase (EC 1.1.1.154)	protein	337	42% helix, 20% strand	B1XGB5
B	Ureidoglycolate dehydrogenase (EC 1.1.1.154)	protein	315	42% helix, 20% strand	B1XGB5

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	524	0.71	0.80	56	empty
2	559	0.70	0.79	60	empty
3	134	0.39	0.74	27	empty
4	58	0.29	0.74	17	empty
5	55	0.28	0.75	12	empty

Interfaces

1 interface between chains.

A–B · 3062 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

4FJS · Crystal structure of ureidoglycolate dehydrogenase enzyme in apo form · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B1XGB5
Elsewhere: RCSB PDB 4FJS · PDBe 4FJS · UniProt B1XGB5

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