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Structure of human sun-kash complex

Analyse Structure of human sun-kash complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FI9
Type: protein
Length: 209 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sun domain-containing protein 2; Nesprin-2
UniProt: Q9UH99, Q8WXH0
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sun domain-containing protein 2	protein	195	13% helix, 39% strand	Q9UH99
B	Nesprin-2	protein	14	0% helix, 29% strand	Q8WXH0

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.49	0.84	19	empty

Interfaces

1 interface between chains.

A–B · 576 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4FI9 · Structure of human SUN-KASH complex · the same entry in another collection · chain A against A, TM-score 1.00
Q9UH99 · AlphaFold monomer V2.0 prediction for sun domain-containing protein 2 (Q9UH99) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UH99
Every structure of UniProt Q8WXH0
Elsewhere: RCSB PDB 4FI9 · PDBe 4FI9 · UniProt Q9UH99 · UniProt Q8WXH0

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