Research workbench
Catalytic domain of germination-specific lytic tansglycosylase sleb from bacillus anthracis
Analyse Catalytic domain of germination-specific lytic tansglycosylase sleb from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FET
- Type
- protein
- Length
- 245 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spore cortex-lytic enzyme prepeptide
- UniProt
- Q81PQ3
- Ligands
- NA
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Spore cortex-lytic enzyme prepeptide | protein | 123 | 45% helix, 10% strand | Q81PQ3 |
| A | Spore cortex-lytic enzyme prepeptide | protein | 122 | 46% helix, 10% strand | Q81PQ3 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 370 | 0.58 | 0.75 | 33 | empty |
| 2 | 150 | 0.41 | 0.74 | 22 | empty |
| 3 | 72 | 0.33 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- B–A · 356 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 4FET · Catalytic domain of germination-specific lytic tansglycosylase SleB from Bacillus… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q81PQ3
- Elsewhere: RCSB PDB 4FET · PDBe 4FET · UniProt Q81PQ3
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